Bio Spec Industries

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Cell Disrupter Selection Table. Click link for image.

 

 

Animal Tissue Plant Tissue Yeast and Fungi Bacteria Disrupt Timeb Relative Costc Requires Cooling?d Requires Prechop? Scale-up Available?

SoniBeast

MiniBeadbeater-1+

MiniBeadbeater-16

MiniBeadbeater-25

Mini-Beadbeater-96

++++
++++
++++
++++
3 2 or 3 Yes Yes Yes
BeadBeater
 
 
++++
++++
3 2 Yes  
Yes

Tissue-Tearor

BioHomogenizer

++++
++++
 

 

<1 2 No Yes Yes
Hamilton-Beach Blenders
+++
+++
    1 or 2 2 No No Yes

Cryo-Cup
Mortar & Pestle

Spiral Pestle & Microtube

++++
++++
++ ++ 1 1 No Yes No
Tissue Grinder
++++
++++

 

 
5 2 No Yes No

MicroMincera

Lever Pressa

Tissue Pressa

++++
++++
    1 1 or 2 No No No

BioPulverizera

MicroCryoCrushera

++++
++++
    0.1 2 No No No

Table Key:

(a) Fragments tissue samples but usually does not disrupt cells. Often used as a preliminary step to cell lysis.
(b) Typical time, in minutes, for 90 percent cell disruption.  For 'dry- or cryo-milling', grinding times are <30 sec
(c) Purchase price range:

  1.   $10 - $100
  2.   $100 - $1000
  3.   $1000 and up

(d) DNA or RNA beadbeated in the presence of nucleic acid extraction media is an exception. Ditto for proteins extracted in media containing SDS detergent.