Cell Disrupter Selection Table. Click link for image.

	Animal Tissue	Plant Tissue	Yeast and Fungi	Bacteria	Disrupt Time^b	Relative Cost^c	Requires Cooling?^d	Requires Prechop?	Scale-up Available?
SoniBeast MiniBeadbeater-1+ MiniBeadbeater-16 MiniBeadbeater-25 Mini-Beadbeater-96	++++	++++	++++	++++	3	2 or 3	Yes	Yes	Yes
BeadBeater			++++	++++	3	2	Yes		Yes
Tissue-Tearor BioHomogenizer	++++	++++			<1	2	No	Yes	Yes
Hamilton-Beach Blenders	+++	+++			1 or 2	2	No	No	Yes
Cryo-Cup Mortar & Pestle Spiral Pestle & Microtube	++++	++++	++	++	1	1	No	Yes	No
Tissue Grinder	++++	++++			5	2	No	Yes	No
MicroMincer^a Lever Press^a Tissue Press^a	++++	++++			1	1 or 2	No	No	No
BioPulverizer^a MicroCryoCrusher^a	++++	++++			0.1	2	No	No	No

Table Key:

(a) Fragments tissue samples but usually does not disrupt cells. Often used as a preliminary step to cell lysis.
(b) Typical time, in minutes, for 90 percent cell disruption. For 'dry- or cryo-milling', grinding times are <30 sec
(c) Purchase price range:

$10 - $100
$100 - $1000
$1000 and up

(d) DNA or RNA beadbeated in the presence of nucleic acid extraction media is an exception. Ditto for proteins extracted in media containing SDS detergent.