Prefered 0.6 ml PCR tubes used with the SoniBeast™ Cell Disrupter have locking lids (mfg: Molecular BioProducts). The unique locking feature of this PCR tube offers security comparable to a screw cap microvial. A small locking ball tethered to the vial body engages a groove in the lid to give positive confirmation that the tube is securely locked. Due to very high mixing energies of the SoniBeast, common, non-locking PCR tubes sometimes leak when used with the SoniBeast. It depends on the application and bead load.