SoniBeast - Small Sample Cell Disruptor

The NEW SoniBeast™ cell disruptor completely disrupts small samples of tissue or cells in seconds rather than minutes. It holds up to twelve 0.6 ml PCR microtubes each containing 1-100 mg of sample, or six 2 ml microvials each containing 10-400 mg sample.

Other applications for this high speed bead mill are fine grinding non-biological materials (nanoparticles, catalysts, magnetic media or pigments, etc.).

A sample pack of 0.6 ml locking PCR tubes is included with the SoniBeast.  Please order Beads and additional Vials separately.

ATTENTION:  We're really excited about this amazing new cell disrupter.  It's the biggest improvement in bead-mill cell disrupter design since we invented the Minibeadbeater in 1984.  In order to give the "Beast" a good send off and for a LIMITED TIME ONLY, we are DISCOUNTING THE SONIBEAST by lowering the price by 25%. Formerly $1947 now $1584!

Our Price : $0.00

The SoniBeast™* cell disrupter homogenizes both microorganisms and plant and animal tissue using the smashing action of colliding ceramic beads. It departs from contemporary beadbeater machines by oscillating tubes and microvials at a rate of 20,000 oscl/min...some 5 to 50 times faster than currently available beadbeating machines.

As expected, when beads within the tubes are moving at these high rates, cell disruption occurs much faster.  Disruption is completed in a few seconds rather than minutes.  The operation of SoniBeast cell disrupter has also been simplified.  Manual clamping of tubes or vials is not required and the machine is operated by the push of a single button. Its capacity is twelve small samples (1-100mg) in 0.6 ml PCR microtubes or six larger samples (10-400 mg) in 1.5 or 2 ml microvials.

The SoniBeast is quieter and has a small footprint.  Unlike other bead mill devices designed for cell disruption, the physical position of vials remain unchanged after beadbeating, thus offering facile integration with robotic systems.

*Patent pending

  • Processes one to twelve 0.6 ml locking-cap PCR tubes each holding 1-100 mg (wet weight) of tissue or cells at ultra-high shaking energies or one to six 2 ml screw-cap microvials each holding 10-400 mg (wet weight) tissue or cells at conventional beadbeater shaking energies
  • Motor Specifications: 110-120 V~AC, 1.6A, 21000 rpm
  • Manual pulse or timed operation (0.5, 2, 5, 10, 20, 40, and 60 sec with auto-reset)
  • Footprint: 5" wide x 16" deep.  Seven inches high. Weight 11 pounds
  • Two year Warranty

What's different about this beadbeater?

The SoniBeast departs from the traditional back-and-forth mechanical motion of most bead mill-type cell disrupters. Rather, vials are vortexed at an unheard of high speed of 20,000 oscillations/minute.  The mixing and grinding energy is many times higher than conventional bead milling or vortexing.  Using 0.6 ml PCR tubes, lysis is completed in seconds rather than minutes.

The SoniBeast can process smaller samples.  By using 0.6 ml PCR tubes with locking caps, 1-100 milligrams of tissue can be lysed in 100 - 400 microliters of extraction media.  The SoniBeast can also process up to six larger sized samples in conventional 1.5 and 2 ml microvials using the established, milder grinding conditions described in published beadbeating protocols.

In a typical protocol, half of the 0.6 ml PCR tube is filled with beads. Then 1 - 100 mg of sample is added and the the remaining tube space is filled nearly to the top with extraction media.  The sealed tube(s) is inserted into the circular tube holder containing 12 holes (Note that no hold-down cap is not needed!) and the SoniBeast is operated with the touch of a single button.  Beadbeating times are typically 5-20 seconds.

The bottom line?  Simpler and quicker!

Detailed operating instructions:

  • Because of the very high bead agitating energy of the SoniBeast, locking PCR tubes or screw cap microvials are required.  For guidance in selecting beads, 0.6 ml locking PCR tubes or 2 ml microvials for the SoniBeast see links for accessories at the bottom of this web page.
  • Targeting disruption of VERY small tissue sample sizes - even down to single cell disruption, we designed our SONIBEAST prototype machines utilizing 0.2 ml microtubes.  While, comparitive performance trials of the prototype in select University labs received rave reviews, some users commented on how challenging it was to handle these tiny 0.2 ml tubes.  We decided to upsize to 0.6 ml microtubes in the commercial model.  Nevertheless, it is very easy to convert the commercial SONIBEAST back to handling these tiny tubes.  It can be done in a matter of minutes using a low cost kit we will be offering in the near future.