Beadbeating (bead milling) is the preferred laboratory method for disruption of cells to recover intracellular proteins, nucleic acids and organelles. It's fast, efficient and and safe.
First to introduce this method of cell disruption to the R&D laboratory in 1979, BioSpec Products now produces seven different models of beadbeater. Each is optimized for different sample size and capacity. Depending on the model chosen, 20 to 2000 samples can easily be processed in an afternoon. The models can be divided into three catagories based on the way the beads are agitated:
The NEW SoniBeast™ bead mill uses a new, patent-pending bead mixing technology. It delivers much faster cell disruption (up to 10X) compared to conventional bead mill-type cell disrupters and can process smaller samples. The SoniBeast's capacity is twelve 0.6 ml microtubes or six 2 ml microvials.
The MiniBeadbeater™ series disrupts cells using the standard 3/4" to 1", back-and-forth shaking pattern. Sample capacities of the models vary from 1 to 48 using 2 ml or 7 ml vials or 96 to 192 using deep well microplates. Typical sample sizes per vial or well range from 1 mg to 1.5 g (wet weight) of tissue or packed cells.
MiniBeadbeater shaking energies equal or exceed all comparable brands of beadbeater.
The larger capacity Beadbeater™ processes 1-80 g (wet weight) of microorganisms or monocellular plant or animal cells. Its most frequent application is recovery of intracellular proteins.
The beadbeating method of cell disruption can be scaled up to pilot plant and production levels.
Product descriptions follow...
The best laboratory-scale homogenizer for disrupting aqueous suspensions of yeast or bacteria. The BeadBeater comes complete with everything you need with a 350 ml polycarbonate chamber, rotor assembly, motor base, ice-water cooling jacket and one pound of glass beads.
Indicate your glass bead size choice by adding -101, -105 or -110 (which is 0.1, 0.5, or 1.0 mm diameter) to the end of the catalog number (example: 1107900-105). See our Bead link in the Browse box to the left for guidance on selecting bead size. Bead compositions other than glass should be order separately. If you require a european/asian 230 VAC unit, please select a model that ends in -EUR.
The µ-MiniBeadbeater is an entry-level, small sample cell disruptor and grinder. Disruption performance is fully comparable to our other MBB models. For applications requiring a selection of shaking speeds, see the MiniBeadbeater-1 and MiniBeaadbeater-24. For processing more than one sample at a time, see MBB-16, MBB-24 and MBB-96.
Cat. No. TP308, 115 volt
Cat. No. TP308EUR, 230 volt
The Mini-Beadbeater-16 is a high-energy cell disrupter designed to handle four to sixteen samples at a time.
--Cat. No. 607, Mini-BeadBeater-16, 115 volt, with safety shield (not shown in photo)
Cat. No. 607EUR, Mini-Beadbeater-16, 220-240 volt
--Beads and vials must be purchased separately. For selecting Beads and Vials see the links in Browse box in the left margin.
--NOTE for European buyers! The Mini-Beadbeater-16 is currently not CE certified. However, the higher vial capacity MBB-24 is CE certified.
The Mini-Beadbeater-24 disrupts up to 24 microbial or tissue samples with better than 95 percent efficiency. Cells are disrupted quickly and safely in the sealed system. The apparatus is easy to clean, has a small footprint and is essentially maintenance free. Compared to the Minibeadbeater-16, this Beadbeater adds advanced electronics for enhanced motor function, continuous variable shaking speeds of 2000-3800 strokes/min, a 30% increase in microvial capacity and CE certification.
Cat. No. 112011, Mini-BeadBeater-24, 115 volt, with safety shield and 2 ml vial cassette.
Cat. No. 112011EUR, Mini-Beadbeater-24, 230 volts, with safety shield and 2 ml cassette.
NOTE for European buyers! The Mini-Beadbeater-24 is CE certified.
The Mini-Beadbeater-96 is high-energy, high-throughput cell disrupter. In a single 1-3 minute batch run it handles up to 192 samples using a deep-well microplate format or 45 samples in 1.5 or 2 ml screw-cap microvials. In a busy day thousands of samples can be processed.
Cat. No. 1001, Mini-Beadbeater-96, 115 volt.
Cat. No. 1001EUR, Mini-Beadbeater-96, 230 volt.
One microvial rack, 702VH45, is included. Beads and vials will vary with the application and should be ordered separately. For selecting Beads and Vials see their links in Browse box in the left margin.
The NEW SoniBeast™ cell disruptor completely disrupts small samples of tissue or cells in seconds rather than minutes. It holds up to twelve 0.6 ml PCR microtubes each containing 1-100 mg of sample, or six 2 ml microvials each containing 10-400 mg sample.
Other applications for this high speed bead mill are fine grinding non-biological materials (nanoparticles, catalysts, magnetic media or pigments, etc.).
A sample pack of 0.6 ml locking PCR tubes is included with the SoniBeast. Please order Beads and additional Vials separately.
ATTENTION: We're really excited about this amazing new cell disrupter. It's the biggest improvement in bead-mill cell disrupter design since we invented the Minibeadbeater in 1984. In order to give the "Beast" a good send off and for a LIMITED TIME ONLY, we are DISCOUNTING THE SONIBEAST by lowering the price by 25%. Formerly $1947 now $1584!