Beadbeating (bead milling) is the preferred laboratory method for disruption of cells to recover intracellular proteins, nucleic acids and organelles. It's fast, efficient and and safe.
First to introduce this method of cell disruption to the R&D laboratory in 1979, BioSpec Products now produces six different models of beadbeater. Each is optimized for different sample size and capacity. Depending on the model chosen, 20 to 2000 samples can easily be processed in an afternoon. The models can be divided into three catagories based on the way the beads are agitated:
The NEW SoniBeast™ bead mill uses a new, patent-pending bead mixing technology. It delivers much faster cell disruption (up to 10X) compared to conventional bead mill-type cell disrupters and can process smaller samples. The SoniBeast's capacity is twelve 0.6 ml microtubes or six 2 ml microvials.
There are four models of MiniBeadbeater™ cell disrupter. All use standard 3/4" - 1", back-and-forth shaking patterns and deliver protcol-compatibity within the group. The µ-MBB, MBB-16 and MBB-25 use 2 or 7 ml microvials. The high through-put MBB-96 holds one or two deep well microplates or a rack of 48 mcrovials. Acceptible sample sizes range from 1 mg to 1.5 g (wet weight) of tissue or packed cells. MiniBeadbeater shaking energies equal or exceed all competitive brands of shaking-type bead mill.
The BeadBeater™ is a larger capacity beadbeater that can processes 10-80 g (wet weight) of microorganisms or monocellular plant or animal cells. It uses a fast turning rotor to agitate the beads within a chamber. It is commonly used to disrupt cells for production of native or expressed intracellular proteins and, unlike most other lab methods of cell disruption, can easily be scaled up to pilot plant and full production levels.
Product descriptions follow...
The best laboratory-scale homogenizer for disrupting aqueous suspensions of yeast or bacteria. The BeadBeater comes complete with everything you need with a 350 ml polycarbonate chamber, rotor assembly, motor base, ice-water cooling jacket and one pound of glass beads.
Indicate your glass bead size choice by adding -101, -105 or -110 (which is 0.1, 0.5, or 1.0 mm diameter) to the end of the catalog number (example: 1107900-105). See our Bead link in the Browse box to the left for guidance on selecting bead size. Bead compositions other than glass should be order separately. If you require a european/asian 230 VAC unit, please select a model that ends in -EUR.
The Mini-Beadbeater-16 is a high-energy cell disrupter designed to handle four to sixteen samples at a time.
--Cat. No. 607, Mini-BeadBeater-16, 115 volt, with safety shield (not shown in photo)
Cat. No. 607EUR, Mini-Beadbeater-16, 220-240 volt
--Beads and vials must be purchased separately. For selecting Beads and Vials see the links in Browse box in the left margin.
--NOTE for European buyers! The Mini-Beadbeater-16 is currently not CE certified. However, the higher vial capacity MBB-24 is CE certified.
The Mini-Beadbeater-24 disrupts up to 24 microbial or tissue samples with better than 95 percent efficiency. Cells are disrupted quickly and safely in the sealed system. The apparatus is easy to clean, has a small footprint and is essentially maintenance free. Compared to the Minibeadbeater-16, this Beadbeater adds advanced electronics for enhanced motor function, continuous variable shaking speeds of 2000-3800 strokes/min, a 30% increase in microvial capacity and CE certification.
Cat. No. 112011, Mini-BeadBeater-24, 115 volt, with safety shield and 2 ml vial cassette.
Cat. No. 112011EUR, Mini-Beadbeater-24, 230 volts, with safety shield and 2 ml cassette.
NOTE for European buyers! The Mini-Beadbeater-24 is CE certified.
The Mini-Beadbeater-96 is high-energy, high-throughput cell disrupter. In a single 1-3 minute batch run it handles up to 192 samples using a deep-well microplate format or 45 samples in 1.5 or 2 ml screw-cap microvials. In a busy day thousands of samples can be processed.
Cat. No. 1001, Mini-Beadbeater-96, 115 volt.
Cat. No. 1001EUR, Mini-Beadbeater-96, 230 volt.
One 45 capacity microvial rack, 702VH45, is included. Beads and vials will vary with the application and should be ordered separately. For selecting Beads and Vials see their links in Browse box in the left margin.
- Incredibly Fast
- 1 to 12 Sample Capacity
- Simple One Button Operation
The NEW SoniBeast™ high energy bead-mill cell disruptor completely disrupts small samples of tissue or cells in seconds rather than minutes. It holds up to twelve 0.6 ml PCR microtubes each containing 1-100 mg of sample, or six 2 ml microvials each containing 10-400 mg sample.
Other applications include fine grinding of small quanties of non-biological materials (eg., nanoparticles, catalysts, magnetic media, pigments).
ATTENTION: We're really excited about this amazing new cell disrupter. It's the biggest improvement in bead-mill cell disrupter design since BioSpec Products invented the Minibeadbeater in 1984. In order to give our "Beast" a great send off, and for a LIMITED TIME ONLY, we are EXTENDING OUR DISTRIBUTOR DISCOUNT TO ANY BUYER WHO ORDERS A NEW SONIBEAST from BioSpec Products. The list price of $1947 will be discounted 25% to $1584!